Multiple or severe root resorptions are not associated with systemic factors, individual susceptibility, family tendency or individual predisposition

Multiple or severe root resorptions, still often assigned to systemic changes, particularly endocrinopathies, are seen when the severity of alveolar bone loss is great, especially during orthodontic movements.18,19,20
In bone turnover, matrix deposition alternates continuously with bone resorption at different sites and times. This dynamic process enables the bone to adapt to the functional demands of each skeletal area and to actively participate in the maintenance of the mineral homeostasis to control serum calcium and phosphorus concentrations.2,3,6,15 The skeleton renews completely at variable time intervals according to the patient?s age.22
Teeth, particularly root structures, do not have bone turnover,1,8,12,17 a consequence of the activity of osteoblasts, osteocytes, macrophages and osteoclasts. These cells organize in basic multicellular units (BMUs), or bone remodeling cells, and receive stimuli from systemic and local mediators found in membrane surface receptors of several cell types, particularly osteoblasts and macrophages.2,7,22 […]