Serum insulin-like growth factor-1 levels in females and males in different cervical vertebral maturation stages

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Edition V20N02 | Year 2015 | Editorial Original Article | Pages 68 to 75

Shreya Gupta , Anuradha Deoskar , Puneet Gupta , Sandhya Jain

Objective: The aim of this cross sectional study was to assess serum insulin-like growth factor-1 (IGF-1) levels in female and male subjects at various cervical vertebral maturation (CVM) stages. Material and methods: The study sample consisted of 60 subjects, 30 females and 30 males, in the age range of 8-23 years. For all subjects, serum IGF-1 level was estimated from blood samples by means of chemiluminescence immunoassay (CLIA). CVM was assessed on lateral cephalograms using the method described by Baccetti. Serum IGF-1 level and cervical staging data of 30 female subjects were included and taken from records of a previous study. Data were analyzed by Kruska-Wallis and Mann Whitney test. Bonferroni correction was carried out and alpha value was set at 0.003. Results: Peak value of serum IGF-1 was observed in cervical stages CS3 in females and CS4 in males. Differences between males and females were observed in mean values of IGF-1 at stages CS3, 4 and 5. The highest mean IGF-1 levels in males was observed in CS4 followed by CS5 and third highest in CS3; whereas in females the highest mean IGF-1 levelswas observed in CS3 followed by CS4 and third highest in CS5. Trends of IGF-1 in relation to the cervical stages also differed between males and females. The greatest mean serum IGF-1 value for both sexes was comparable, for females (397 ng/ml) values were slightly higher than in males (394.8 ng/ml). Conclusions: Males and females showed differences in IGF-1 trends and levels at different cervical stages.

Female, Male, Cervical vertebrae, Insulin-like growth factor 1,

Gupta S, Deoskar A, Gupta P, Jain S. Serum insulinlike growth factor-1 levels in females and males in different cervical vertebral maturation stages. Dental Press J Orthod. 2015 Mar-Apr;20(2):68-75. DOI: http://

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