Use of chondroitin sulphate and glucosamine sulphate in degenerative changes in TMJ: A systematic review

Admin Dental Press

Edition V17N04 | Year 2012 | Editorial Original Article | Pages 182 to 186

Eduardo Machado , Patricia Machado , Paulo Afonso Cunali

Introduction: Degenerative changes in Temporomandibular Joint (TMJ) have increased in prevalence and severity over the years. Within this context, it´s necessary to obtain safe and effective therapies for control and management of the patient in cases of osteoarthritis and osteoarthrosis of the TMJ. Therapeutic options range from intra-articular infiltration protocols, occlusal splints, pharmacological therapies and physiotherapy and educational measures. The alternative treatment with structure-modifying agents, like as chondroitin and glucosamine sulfates, showed promising results, and especially safety. Thus, through a systematic literature review, this study aimed to analyze and discuss effectiveness and safety of chondroitin and glucosamine in degenerative changes of the TMJ. Methods: Survey in research bases: MEDLINE, Cochrane, EMBASE, Pubmed, Lilacs and BBO, between the years of 1966 and January 2009, with focus in randomized clinical trial (RCTs) and quasi-randomized clinical trials, systematic reviews and meta-analysis. Results: After application of the inclusion criteria was reached 2 articles, both randomized controlled double-blind clinical trials, which evaluated the effectiveness of chondroitin and glucosamine in degenerative changes of the TMJ. Conclusions: There is necessary further RCT, with representative samples and long follow-up time, to obtainment cause-effect relationships more precise and to achieve an objective and effective protocol involving chondroitin and glucosamine in cases of degenerative changes of the TMJ.

Chondroitin, Glucosamine, Temporomandibular joint, Temporomandibular disorder, Osteoarthrosis, Osteoarthritis,

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